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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1550357
Species: Mus musculus
RGD Object: Gene
Symbol: Fth1
Name: ferritin heavy polypeptide 1
Acc ID: CHEBI:50385
Term: hemin
Definition: It is used as a prescription medication to relieve repeated attacks of acute intermittent porphyria related to the menstrual cycle in affected women.
Chemical ID: MESH:D006427
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fth1increases expressionEXP 6480464CTDHemin results in increased expression of FTH1 mRNAPMID:29749404
Fth1increases expressionISOFth1 (Rattus norvegicus)6480464CTDHemin results in increased expression of FTH1 mRNA; Hemin results in increased expression of FTH1 proteinPMID:15893546 PMID:16568477 PMID:17469137
Fth1increases expressionISOFTH1 (Homo sapiens)6480464CTDHemin results in increased expression of FTH1 proteinPMID:31054940
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