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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1306693
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bach1
Name: BTB domain and CNC homolog 1
Acc ID: CHEBI:50385
Term: hemin
Definition: It is used as a prescription medication to relieve repeated attacks of acute intermittent porphyria related to the menstrual cycle in affected women.
Chemical ID: MESH:D006427
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bach1affects localizationISOBACH1 (Homo sapiens)6480464CTDHemin affects the localization of BACH1 proteinPMID:33434570
Bach1increases expressionISOBACH1 (Homo sapiens)6480464CTDHemin results in increased expression of BACH1 mRNA; Hemin results in increased expression of BACH1 proteinPMID:31518892
Bach1multiple interactionsISOBACH1 (Homo sapiens)6480464CTD[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Hemin] affects the localization of BACH1 protein; [benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Hemin] results in increased expression of BACH1 protein; [Hemin co-treated with benzyloxycarbonylleucyl-leucyl-leucine aldehyde] results in increased expression of BACH1 mRNA; BACH1 protein affects the reaction [Hemin results in increased expression of HMOX1 mRNA]; Hemin inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of BACH1 protein]; Hemin results in decreased localization of and results in decreased activity of BACH1 proteinPMID:18550526 PMID:31518892 PMID:33434570 PMID:36096218
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