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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61974
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hpd
Name: 4-hydroxyphenylpyruvate dioxygenase
Acc ID: CHEBI:50378
Term: nitisinone
Definition: A cyclohexanone that is cyclohexane-1,3-dione substituted at position 2 by a 2-nitro-4-(trifluoromethyl)benzoyl group. It is used in the treatment of hereditary tyrosinemia type 1.
Chemical ID: MESH:C077073
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hpdmultiple interactionsISORGD:622676480464CTD[nitisinone results in decreased activity of HPD protein] which results in decreased expression of GCLC mRNA; [nitisinone results in decreased activity of HPD protein] which results in decreased expression of GCLM mRNA; [nitisinone results in decreased activity of HPD protein] which results in decreased expression of HMOX1 mRNA; [nitisinone results in decreased activity of HPD protein] which results in decreased expression of NQO1 mRNAPMID:12899938
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