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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1557448
Species: Mus musculus
RGD Object: Gene
Symbol: Top2b
Name: topoisomerase (DNA) II beta
Acc ID: CHEBI:50225
Term: razoxane
Definition: A N-alkylpiperazine that has formula C11H16N4O4.
Chemical ID: MESH:D011929
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Top2baffects bindingISORGD:13506376480464CTDRazoxane binds to TOP2B protein

PMID:17875725
Top2bmultiple interactionsISORGD:15861566480464CTDBortezomib inhibits the reaction [Razoxane results in increased degradation of and results in decreased expression of TOP2B protein], Razoxane results in increased degradation of and results in decreased expression of TOP2B protein

PMID:17875725
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.