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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731885
Species: Mus musculus
RGD Object: Gene
Symbol: Alpl
Name: alkaline phosphatase, liver/bone/kidney
Acc ID: CHEBI:50207
Term: sophoraflavanone B
Definition: A trihydroxyflavanone that is (S)-naringenin having a prenyl group at position 8.
Chemical ID: MESH:C119737
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Alplincreases activityISOALPL (Homo sapiens)6480464CTD8-prenylnaringenin results in increased activity of ALPL proteinPMID:16019205
Alplincreases expressionISOALPL (Homo sapiens)6480464CTD8-prenylnaringenin results in increased expression of ALPL mRNAPMID:16019205
Alplmultiple interactionsISOALPL (Homo sapiens)6480464CTD[8-prenylnaringenin binds to ESR1 protein] which results in increased activity of ALPL protein; fulvestrant inhibits the reaction [[8-prenylnaringenin binds to ESR1 protein] which results in increased activity of ALPL protein]PMID:12650720
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