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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620365
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hnrnpd
Name: heterogeneous nuclear ribonucleoprotein D
Acc ID: CHEBI:50154
Term: 1,1-bis(2-aminoethyl)-2-hydroxy-3-oxotriazane
Definition: A nitroso compound that is triazane in which the the nitrogen at position 1 is substituted by two 2-aminoethyl groups, that at position 2 is substituted by a hydroxy group, and that at position 3 is substituted by an oxo group.
Chemical ID: MESH:C094210
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hnrnpdincreases expressionEXP 6480464CTD2, 2'-(hydroxynitrosohydrazono)bis-ethanamine results in increased expression of HNRNPD protein

PMID:16683234
Hnrnpdmultiple interactionsEXP 6480464CTD2, 2'-(hydroxynitrosohydrazono)bis-ethanamine promotes the reaction [HNRNPD protein binds to MMP9 3' UTR], HNRNPD mutant form inhibits the reaction [2, 2'-(hydroxynitrosohydrazono)bis-ethanamine inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased activity of MMP9 protein]]

PMID:16683234
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.