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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69062
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdkn1b
Name: cyclin-dependent kinase inhibitor 1B
Acc ID: CHEBI:5014
Term: fenvalerate
Definition: A carboxylic ester obtained by formal condensation between 2-(4-chlorophenyl)-3-methylbutyric acid and cyano(3-phenoxyphenyl)methanol.
Chemical ID: MESH:C017690
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdkn1bdecreases expressionISOCDKN1B (Homo sapiens)6480464CTDfenvalerate results in decreased expression of CDKN1B mRNA; fenvalerate results in decreased expression of CDKN1B proteinPMID:22850687
Cdkn1bdecreases response to substanceISOCDKN1B (Homo sapiens)6480464CTDCDKN1B protein results in decreased susceptibility to fenvaleratePMID:22850687
Cdkn1bmultiple interactionsISOCDKN1B (Homo sapiens)6480464CTDCDKN1B protein inhibits the reaction [fenvalerate results in increased expression of CDK2 mRNA]PMID:22850687
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