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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2279
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cat
Name: catalase
Acc ID: CHEBI:5014
Term: fenvalerate
Definition: A carboxylic ester obtained by formal condensation between 2-(4-chlorophenyl)-3-methylbutyric acid and cyano(3-phenoxyphenyl)methanol.
Chemical ID: MESH:C017690
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Catdecreases activityEXP 6480464CTDfenvalerate metabolite results in decreased activity of CAT protein, fenvalerate results in decreased activity of CAT protein

PMID:15892188
Catincreases activityEXP 6480464CTDfenvalerate results in increased activity of CAT protein

PMID:10355540
Catmultiple interactionsEXP 6480464CTD[cypermethrin co-treated with fenvalerate] results in increased activity of CAT protein, CAT protein inhibits the reaction [fenvalerate results in increased cleavage of CASP3 protein], CAT protein inhibits the reaction [fenvalerate results in increased cleavage of PARP1 protein]

PMID:10355540, PMID:30307764
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.