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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1346751
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP2B6
Name: cytochrome P450 family 2 subfamily B member 6
Acc ID: CHEBI:5014
Term: fenvalerate
Definition: A carboxylic ester obtained by formal condensation between 2-(4-chlorophenyl)-3-methylbutyric acid and cyano(3-phenoxyphenyl)methanol.
Chemical ID: MESH:C017690
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP2B6decreases activityEXP 6480464CTDfenvalerate results in decreased activity of CYP2B6 proteinPMID:22634058
CYP2B6increases activityEXP 6480464CTDfenvalerate results in increased activity of CYP2B6 proteinPMID:22310298
CYP2B6increases expressionEXP 6480464CTDfenvalerate results in increased expression of CYP2B6 mRNA; fenvalerate results in increased expression of CYP2B6 proteinPMID:15548381 PMID:22310298
CYP2B6multiple interactionsEXP 6480464CTDfenvalerate inhibits the reaction [CYP2B6 protein results in increased hydroxylation of Bupropion]PMID:22634058
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