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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735868
Species: Homo sapiens
RGD Object: Gene
Symbol: NQO1
Name: NAD(P)H quinone dehydrogenase 1
Acc ID: CHEBI:50131
Term: 5-aza-2'-deoxycytidine
Definition: A 2'-deoxyribonucleoside that has formula C8H12N4O4.
Chemical ID: MESH:C014347
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases methylationEXP 6480464CTDDecitabine results in decreased methylation of NQO1 promoter

PMID:15763338
increases expressionEXP 6480464CTDDecitabine results in increased expression of NQO1 mRNA

PMID:19194470
decreases methylationISORGD:25036480464CTDDecitabine results in decreased methylation of NQO1 promoter

PMID:29889218
increases expressionISORGD:25036480464CTDDecitabine results in increased expression of NQO1 mRNA

PMID:29889218
multiple interactionsISORGD:25036480464CTD[Decitabine results in decreased methylation of NQO1 promoter] which results in increased expression of NQO1 mRNA

PMID:29889218
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.