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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733730
Species: Mus musculus
RGD Object: Gene
Symbol: Mlh1
Name: mutL homolog 1
Acc ID: CHEBI:50131
Term: 5-aza-2'-deoxycytidine
Definition: A 2'-deoxyribonucleoside that has formula C8H12N4O4.
Chemical ID: MESH:C014347
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mlh1affects methylationISOMLH1 (Homo sapiens)6480464CTDDecitabine affects the methylation of MLH1 promoterPMID:18069755
Mlh1decreases methylationISOMLH1 (Homo sapiens)6480464CTDDecitabine results in decreased methylation of MLH1; Decitabine results in decreased methylation of MLH1 promoterPMID:19032668 PMID:19080631 PMID:21875463 PMID:25043185
Mlh1increases expressionISOMLH1 (Homo sapiens)6480464CTDDecitabine results in increased expression of MLH1; Decitabine results in increased expression of MLH1 mRNA; Decitabine results in increased expression of MLH1 proteinPMID:19032668 PMID:19080631 PMID:19259094 PMID:19417133 PMID:21875463 PMID:22082530 PMID:25043185
Mlh1multiple interactionsISOMLH1 (Homo sapiens)6480464CTD[Decitabine co-treated with trichostatin A] affects the methylation of MLH1 promoter; belinostat promotes the reaction [Decitabine results in increased expression of MLH1 protein]; Decitabine affects the reaction [Estradiol results in decreased expression of MLH1 mRNA]; Decitabine inhibits the reaction [Oxygen deficiency results in decreased expression of MLH1 mRNA]; Decitabine inhibits the reaction [Oxygen deficiency results in increased methylation of MLH1 promoter]PMID:18069755 PMID:19259094 PMID:22082530 PMID:25043185
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