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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69342
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Serpinb5
Name: serpin family B member 5
Acc ID: CHEBI:50131
Term: 5-aza-2'-deoxycytidine
Definition: A 2'-deoxyribonucleoside that has formula C8H12N4O4.
Chemical ID: MESH:C014347
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionISORGD:690896480464CTDDecitabine affects the expression of SERPINB5 mRNA

PMID:16799634
decreases methylationISORGD:690896480464CTDDecitabine results in decreased methylation of SERPINB5 gene

PMID:18060631
increases expressionISORGD:690896480464CTDDecitabine results in increased expression of SERPINB5 mRNA

PMID:18060631, PMID:18291368
multiple interactionsISORGD:690896480464CTD[Decitabine co-treated with trichostatin A] results in decreased methylation of SERPINB5 promoter

PMID:18291368
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.