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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621676
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Acta2
Name: actin alpha 2, smooth muscle
Acc ID: CHEBI:50131
Term: 5-aza-2'-deoxycytidine
Definition: A 2'-deoxyribonucleoside that has formula C8H12N4O4.
Chemical ID: MESH:C014347
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Acta2decreases expressionEXP 6480464CTDDecitabine results in decreased expression of ACTA2 mRNAPMID:22056649
Acta2multiple interactionsEXP 6480464CTDDecitabine inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in increased expression of ACTA2 protein]; Decitabine inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; Decitabine inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]PMID:24211420 PMID:30010033
Acta2affects expressionISOACTA2 (Homo sapiens)6480464CTDDecitabine affects the expression of ACTA2 mRNAPMID:23300844
Acta2multiple interactionsISOACTA2 (Homo sapiens)6480464CTDDecitabine inhibits the reaction [nickel monoxide results in increased expression of ACTA2 protein]PMID:36066426
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