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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62159
Species: Mus musculus
RGD Object: Gene
Symbol: Casp9
Name: caspase 9
Acc ID: CHEBI:50131
Term: 5-aza-2'-deoxycytidine
Definition: A 2'-deoxyribonucleoside that has formula C8H12N4O4.
Chemical ID: MESH:C014347
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp9increases cleavageISOCASP9 (Homo sapiens)6480464CTDDecitabine results in increased cleavage of CASP9 proteinPMID:18636160
Casp9multiple interactionsISOCASP9 (Homo sapiens)6480464CTD[Decitabine affects the methylation of CASP9 gene] which affects the expression of CASP9 protein; [Decitabine co-treated with TNFSF10 protein] results in increased activity of CASP9 protein; pifithrin inhibits the reaction [[Decitabine co-treated with Busulfan] results in increased activity of CASP9 protein]PMID:18636160 PMID:18649362 PMID:19732952
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