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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62109
Species: Mus musculus
RGD Object: Gene
Symbol: Col1a1
Name: collagen, type I, alpha 1
Acc ID: CHEBI:50131
Term: 5-aza-2'-deoxycytidine
Definition: A 2'-deoxyribonucleoside that has formula C8H12N4O4.
Chemical ID: MESH:C014347
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Col1a1affects expressionISOCOL1A1 (Homo sapiens)6480464CTDDecitabine affects the expression of COL1A1 mRNAPMID:23300844
Col1a1decreases expressionISOCol1a1 (Rattus norvegicus)6480464CTDDecitabine results in decreased expression of COL1A1 mRNAPMID:22056649
Col1a1increases expressionISOCOL1A1 (Homo sapiens)6480464CTDDecitabine results in increased expression of COL1A1 mRNAPMID:19424577
Col1a1multiple interactionsISOCol1a1 (Rattus norvegicus)6480464CTDDecitabine inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in increased expression of COL1A1 protein]; Decitabine inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; Decitabine inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein]PMID:24211420 PMID:30010033
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