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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2758
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gstp1
Name: glutathione S-transferase pi 1
Acc ID: CHEBI:50131
Term: 5-aza-2'-deoxycytidine
Definition: A 2'-deoxyribonucleoside that has formula C8H12N4O4.
Chemical ID: MESH:C014347
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gstp1decreases methylationISOGSTP1 (Homo sapiens)6480464CTDDecitabine results in decreased methylation of GSTP1 gene; Decitabine results in decreased methylation of GSTP1 promoterPMID:16613325 PMID:18174752 PMID:18676679 PMID:19840838
Gstp1increases expressionISOGSTP1 (Homo sapiens)6480464CTDDecitabine results in increased expression of GSTP1 mRNA; Decitabine results in increased expression of GSTP1 proteinPMID:16613325 PMID:18174752 PMID:18676679 PMID:19396019 PMID:19840838
Gstp1multiple interactionsISOGstp1 (Mus musculus)6480464CTD[Decitabine co-treated with trichostatin A] results in increased expression of GSTP1 mRNAPMID:19444856
Gstp1multiple interactionsISOGSTP1 (Homo sapiens)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Decitabine results in increased expression of GSTP1 protein]; [Decitabine co-treated with trichostatin A] results in increased expression of GSTP1 mRNA; [Decitabine results in decreased methylation of GSTP1 promoter] which results in increased expression of GSTP1 mRNA; Arsenic Trioxide promotes the reaction [Decitabine results in increased expression of GSTP1 mRNA]; Decitabine promotes the reaction [Arsenic Trioxide results in increased expression of GSTP1 mRNA]PMID:16613325 PMID:17891453 PMID:19396019
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