Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1621553
Species: Mus musculus
RGD Object: Gene
Symbol: Rassf1
Name: Ras association (RalGDS/AF-6) domain family member 1
Acc ID: CHEBI:50131
Term: 5-aza-2'-deoxycytidine
Definition: A 2'-deoxyribonucleoside that has formula C8H12N4O4.
Chemical ID: MESH:C014347
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Rassf1affects expressionISORASSF1 (Homo sapiens)6480464CTDDecitabine affects the expression of RASSF1 mRNAPMID:18320071
Rassf1affects methylationISORASSF1 (Homo sapiens)6480464CTDDecitabine affects the methylation of RASSF1 promoterPMID:17526942 PMID:17571247 PMID:17641842 PMID:17671114
Rassf1decreases methylationISORASSF1 (Homo sapiens)6480464CTDDecitabine results in decreased methylation of RASSF1 gene; Decitabine results in decreased methylation of RASSF1 promoterPMID:16613325 PMID:18203293 PMID:19172108 PMID:19440673 PMID:19442645 PMID:19840838 PMID:20079041
Rassf1increases expressionISORASSF1 (Homo sapiens)6480464CTDDecitabine results in increased expression of RASSF1 mRNA; Decitabine results in increased expression of RASSF1 proteinPMID:16613325 PMID:18203293 PMID:19037991 PMID:19172108 PMID:19215824 PMID:19440673 PMID:19442645 PMID:20079041 PMID:22749965
Rassf1multiple interactionsISORASSF1 (Homo sapiens)6480464CTD[[Decitabine co-treated with trichostatin A] affects the methylation of RASSF1 promoter] which affects the expression of RASSF1 mRNA; [Decitabine co-treated with trichostatin A] affects the expression of RASSF1 protein; [Decitabine results in decreased methylation of RASSF1 promoter] which results in increased expression of RASSF1 mRNA; Arsenic Trioxide promotes the reaction [Decitabine results in increased expression of RASSF1 mRNA]; Butyrates promotes the reaction [Decitabine results in decreased methylation of RASSF1 promoter]; Butyrates promotes the reaction [Decitabine results in increased expression of RASSF1 mRNA]; Butyrates promotes the reaction [Decitabine results in increased expression of RASSF1 protein]; Decitabine inhibits the reaction [Cadmium Chloride results in decreased expression of RASSF1 protein]; Decitabine inhibits the reaction [Cadmium Chloride results in increased methylation of RASSF1 promoter]; Decitabine promotes the reaction [Arsenic Trioxide results in increased expression of RASSF1 mRNA]PMID:16613325 PMID:17019711 PMID:17938735 PMID:18203293 PMID:18819746
Go Back to source page   Continue to Ontology report