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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352761
Species: Homo sapiens
RGD Object: Gene
Symbol: RELA
Name: RELA proto-oncogene, NF-kB subunit
Acc ID: CHEBI:50131
Term: 5-aza-2'-deoxycytidine
Definition: A 2'-deoxyribonucleoside that has formula C8H12N4O4.
Chemical ID: MESH:C014347
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
RELAaffects localizationEXP 6480464CTDDecitabine affects the localization of RELA proteinPMID:19117987
RELAmultiple interactionsEXP 6480464CTD[Decitabine co-treated with sodium arsenite] results in decreased expression of RELA protein; Decitabine inhibits the reaction [arsenite results in increased phosphorylation of RELA protein]; Decitabine promotes the reaction [RELA protein binds to IER3 promoter]; TNF protein promotes the reaction [Decitabine promotes the reaction [RELA protein binds to IER3 promoter]]PMID:19117987 PMID:24704393 PMID:30191986
RELAincreases expressionISORela (Mus musculus)6480464CTDDecitabine results in increased expression of RELA mRNAPMID:27915011
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