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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1318375
Species: Mus musculus
RGD Object: Gene
Symbol: Sirt1
Name: sirtuin 1
Acc ID: CHEBI:50103
Term: excitatory amino acid agonist
Definition: An agent that binds to and activates excitatory amino acid receptors.
Chemical ID: MESH:D018690
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sirt1multiple interactionsISOSirt1 (Rattus norvegicus)6480464CTDExcitatory Amino Acid Agonists results in decreased expression of and results in decreased activity of SIRT1 protein; Niacinamide inhibits the reaction [Excitatory Amino Acid Agonists results in decreased expression of and results in decreased activity of SIRT1 protein]PMID:19288225
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