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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733473
Species: Homo sapiens
RGD Object: Gene
Symbol: IRS1
Name: insulin receptor substrate 1
Acc ID: CHEBI:50102
Term: N-methyl-N-nitrosourea
Definition: A member of the class of N-nitrosoureas that is urea in which one of the nitrogens is substituted by methyl and nitroso groups.
Chemical ID: MESH:D008770
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IRS1increases phosphorylationISOIrs1 (Rattus norvegicus)6480464CTDMethylnitrosourea results in increased phosphorylation of IRS1 proteinPMID:16237195
IRS1multiple interactionsISOIrs1 (Rattus norvegicus)6480464CTDHexachlorobenzene inhibits the reaction [Methylnitrosourea results in increased phosphorylation of IRS1 protein]PMID:16237195
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