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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732095
Species: Mus musculus
RGD Object: Gene
Symbol: Pcna
Name: proliferating cell nuclear antigen
Acc ID: CHEBI:50102
Term: N-methyl-N-nitrosourea
Definition: A member of the class of N-nitrosoureas that is urea in which one of the nitrogens is substituted by methyl and nitroso groups.
Chemical ID: MESH:D008770
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pcnaincreases expressionISOPcna (Rattus norvegicus)6480464CTDMethylnitrosourea results in increased expression of PCNA proteinPMID:18155124
Pcnamultiple interactionsISOPcna (Rattus norvegicus)6480464CTD[Methylnitrosourea co-treated with Testosterone] results in increased expression of PCNA protein; Quercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in increased expression of PCNA protein]PMID:25164625
Pcnamultiple interactionsISOPCNA (Homo sapiens)6480464CTDMethylnitrosourea promotes the reaction [MSH2 protein binds to PCNA protein binds to MSH6 protein]PMID:16204460
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