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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68997
Species: Homo sapiens
RGD Object: Gene
Symbol: IGF1R
Name: insulin like growth factor 1 receptor
Acc ID: CHEBI:50102
Term: N-methyl-N-nitrosourea
Definition: A member of the class of N-nitrosoureas that is urea in which one of the nitrogens is substituted by methyl and nitroso groups.
Chemical ID: MESH:D008770
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IGF1Rincreases expressionISOIgf1r (Rattus norvegicus)6480464CTDMethylnitrosourea results in increased expression of IGF1R proteinPMID:16237195
IGF1Rmultiple interactionsISOIgf1r (Rattus norvegicus)6480464CTD[Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in increased expression of IGF1R mRNA; [Estradiol co-treated with Progesterone co-treated with Methylnitrosourea] results in increased expression of IGF1R protein; Hexachlorobenzene inhibits the reaction [Methylnitrosourea results in increased expression of IGF1R protein]PMID:16237195 PMID:22465879
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