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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1550157
Species: Mus musculus
RGD Object: Gene
Symbol: Kras
Name: Kirsten rat sarcoma viral oncogene homolog
Acc ID: CHEBI:50102
Term: N-methyl-N-nitrosourea
Definition: A member of the class of N-nitrosoureas that is urea in which one of the nitrogens is substituted by methyl and nitroso groups.
Chemical ID: MESH:D008770
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Krasincreases mutagenesisEXP 6480464CTDMethylnitrosourea results in increased mutagenesis of KRAS genePMID:12483526 PMID:18062963
Krasdecreases response to substanceISOKras (Rattus norvegicus)6480464CTDKRAS protein results in decreased susceptibility to MethylnitrosoureaPMID:11973638
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