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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3770
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Star
Name: steroidogenic acute regulatory protein
Acc ID: CHEBI:50095
Term: bucladesine
Definition: A 3',5'-cyclic purine nucleotide that is the 2'-butanoate ester and 6-N-butanoyl derivative of 3',5'-cyclic AMP.
Chemical ID: MESH:D003994
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDBucladesine results in increased expression of STAR mRNA

PMID:21693180
multiple interactionsEXP 6480464CTD[Atrazine co-treated with Bucladesine] results in increased expression of STAR mRNA, Atrazine inhibits the reaction [Bucladesine results in increased expression of STAR mRNA], Quercetin inhibits the reaction [[Atrazine co-treated with Bucladesine] results in increased expression of STAR mRNA]

PMID:21693180, PMID:23200735
decreases expressionISORGD:7354136480464CTDBucladesine results in decreased expression of STAR mRNA

PMID:19253104
increases expressionISORGD:113506480464CTDBucladesine results in increased expression of STAR mRNA, Bucladesine results in increased expression of STAR protein

PMID:10964798, PMID:10993823, PMID:11213355, PMID:18787026, PMID:19282384, PMID:19698295, PMID:21979172, PMID:23362264
multiple interactionsISORGD:113506480464CTD27-hydroxycholesterol promotes the reaction [STAR protein promotes the reaction [[Bucladesine co-treated with APOA1 protein] results in increased secretion of Cholesterol]], [[TO-901317 co-treated with LG 100268] promotes the reaction [Bucladesine results in increased phosphorylation of STAR protein]] which results in increased abundance of Progesterone, [Bucladesine co-treated with ciglitazone] results in increased expression of STAR mRNA, [Bucladesine co-treated with ciglitazone] results in increased phosphorylation of STAR protein, [Bucladesine co-treated with LIPE protein] results in increased expression of and results in increased phosphorylation of STAR protein, [Bucladesine promotes the reaction [CREB1 protein modified form binds to STAR promoter]] promotes the reaction [CREBBP protein binds to STAR promoter], [Bucladesine results in increased expression of and results in increased phosphorylation of STAR protein] which results in increased abundance of Progesterone, [Bucladesine results in increased expression of STAR protein] which results in increased abundance of Progesterone, [ciglitazone co-treated with Bucladesine] promotes the reaction [JUN protein results in increased expression of STAR mRNA], [TO-901317 co-treated with LG 100268] promotes the reaction [Bucladesine results in increased phosphorylation of STAR protein], alpha-hexachlorocyclohexane inhibits the reaction [Bucladesine results in increased expression of STAR mRNA], alpha-hexachlorocyclohexane inhibits the reaction [Bucladesine results in increased expression of STAR protein], bisindolylmaleimide I inhibits the reaction [Bucladesine promotes the reaction [CREB1 protein modified form binds to STAR promoter]], bisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [Bucladesine results in increased expression of STAR mRNA]], bisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [Bucladesine results in increased expression of STAR protein]], Bucladesine promotes the reaction [ciglitazone results in increased expression of STAR mRNA], Bucladesine promotes the reaction [ciglitazone results in increased expression of STAR protein], Bucladesine promotes the reaction [CREB1 protein modified form binds to STAR promoter], Bucladesine promotes the reaction [LG 100268 promotes the reaction [[TO-901317 results in increased expression of STAR mRNA] which results in increased abundance of Progesterone]], Bucladesine promotes the reaction [LG 100268 promotes the reaction [[TO-901317 results in increased expression of STAR protein] which results in increased abundance of Progesterone]], Bucladesine promotes the reaction [LG 100268 promotes the reaction [TO-901317 results in increased expression of STAR mRNA]], Bucladesine promotes the reaction [TO-901317 promotes the reaction [[LG 100268 results in increased expression of STAR mRNA] which results in increased abundance of Progesterone]], Bucladesine promotes the reaction [TO-901317 promotes the reaction [[LG 100268 results in increased expression of STAR protein] which results in increased abundance of Progesterone]], Bucladesine promotes the reaction [TO-901317 promotes the reaction [LG 100268 results in increased expression of STAR mRNA]], Bucladesine results in increased expression of and results in increased phosphorylation of STAR mRNA, Bucladesine results in increased expression of and results in increased phosphorylation of STAR protein, CAY 10499 inhibits the reaction [Bucladesine results in increased expression of and results in increased phosphorylation of STAR protein], ciglitazone promotes the reaction [Bucladesine results in increased expression of STAR mRNA], ciglitazone promotes the reaction [Bucladesine results in increased expression of STAR protein], CREB1 protein promotes the reaction [Tetradecanoylphorbol Acetate promotes the reaction [Bucladesine results in increased expression of STAR mRNA]], CREBBP protein promotes the reaction [CREB1 protein promotes the reaction [Tetradecanoylphorbol Acetate promotes the reaction [Bucladesine results in increased expression of STAR mRNA]]], delta-hexachlorocyclohexane inhibits the reaction [Bucladesine results in increased expression of STAR mRNA], delta-hexachlorocyclohexane inhibits the reaction [Bucladesine results in increased expression of STAR protein], GFX 109203x inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [Bucladesine results in increased expression of and results in increased phosphorylation of STAR protein]], Hexachlorocyclohexane inhibits the reaction [Bucladesine results in increased expression of STAR mRNA], Hexachlorocyclohexane inhibits the reaction [Bucladesine results in increased expression of STAR protein], lead acetate inhibits the reaction [Bucladesine results in increased expression of STAR protein], LIPE protein affects the reaction [Bucladesine results in increased expression of and results in increased phosphorylation of STAR protein], LIPE protein affects the reaction [Bucladesine results in increased expression of STAR mRNA], N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Bucladesine promotes the reaction [CREB1 protein modified form binds to STAR promoter]], N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Bucladesine results in increased expression of and results in increased phosphorylation of STAR protein], N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Bucladesine results in increased expression of STAR mRNA], N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [Bucladesine results in increased expression of and results in increased phosphorylation of STAR protein]], NR0B1 protein inhibits the reaction [[Bucladesine results in increased expression of STAR protein] which results in increased abundance of Progesterone], NR0B1 protein inhibits the reaction [NR4A1 protein promotes the reaction [Bucladesine results in increased expression of STAR mRNA]], NR0B1 protein inhibits the reaction [NR5A1 protein promotes the reaction [Bucladesine results in increased expression of STAR mRNA]], NR1H2 protein affects the reaction [CAY 10499 inhibits the reaction [Bucladesine results in increased expression of and results in increased phosphorylation of STAR protein]], NR1H3 protein affects the reaction [CAY 10499 inhibits the reaction [Bucladesine results in increased expression of and results in increased phosphorylation of STAR protein]], NR4A1 protein promotes the reaction [Bucladesine results in increased expression of STAR mRNA], NR4A1 protein promotes the reaction [Tetradecanoylphorbol Acetate promotes the reaction [Bucladesine results in increased expression of STAR mRNA]], NR5A1 protein promotes the reaction [Bucladesine results in increased expression of STAR mRNA], Probucol inhibits the reaction [STAR protein promotes the reaction [[Bucladesine co-treated with APOA1 protein] results in increased secretion of Cholesterol]], STAR protein promotes the reaction [[Bucladesine co-treated with APOA1 protein] results in increased expression of ABCA1 mRNA], STAR protein promotes the reaction [[Bucladesine co-treated with APOA1 protein] results in increased secretion of Cholesterol], Tetradecanoylphorbol Acetate promotes the reaction [[Bucladesine results in increased expression of and results in increased phosphorylation of STAR protein] which results in increased abundance of Progesterone], Tetradecanoylphorbol Acetate promotes the reaction [Bucladesine promotes the reaction [CREB1 protein modified form binds to STAR promoter]], Tetradecanoylphorbol Acetate promotes the reaction [Bucladesine results in increased expression of and results in increased phosphorylation of STAR mRNA], Tetradecanoylphorbol Acetate promotes the reaction [Bucladesine results in increased expression of and results in increased phosphorylation of STAR protein], Tetradecanoylphorbol Acetate promotes the reaction [Bucladesine results in increased expression of STAR mRNA], Tetradecanoylphorbol Acetate promotes the reaction [Bucladesine results in increased expression of STAR protein], Tetradecanoylphorbol Acetate promotes the reaction [Bucladesine results in increased phosphorylation of STAR protein], U 0126 inhibits the reaction [Bucladesine results in increased phosphorylation of STAR protein], U 0126 inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [Bucladesine results in increased phosphorylation of STAR protein]]

PMID:10993823, PMID:11213355, PMID:18755854, PMID:18787026, PMID:19282384, PMID:19698295, PMID:20083572, PMID:21047949, PMID:23362264
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.