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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69423
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Srebf1
Name: sterol regulatory element binding transcription factor 1
Acc ID: CHEBI:5001
Term: fenofibrate
Definition: A chlorobenzophenone that is (4-chlorophenyl)(phenyl)methanone substituted by a [2-methyl-1-oxo-1-(propan-2-yloxy)propan-2-yl]oxy group at position 1 on the phenyl ring.
Chemical ID: MESH:D011345
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTD[Fenofibrate co-treated with resveratrol] inhibits the reaction [Fructose results in increased expression of SREBF1 mRNA]

PMID:26973390
increases expressionISORGD:694746480464CTDFenofibrate results in increased expression of SREBF1 mRNA

PMID:23063693
multiple interactionsISORGD:694736480464CTDFenofibrate inhibits the reaction [Fatty Acids, Nonesterified results in increased expression of SREBF1 mRNA], Fenofibrate inhibits the reaction [Fatty Acids, Nonesterified results in increased expression of SREBF1 protein]

PMID:24735863
multiple interactionsISORGD:694746480464CTDFenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SREBF1 mRNA], NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SREBF1 mRNA]], NR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of SREBF1 mRNA], NR1H3 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of SREBF1 mRNA]

PMID:19593819, PMID:23063693
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.