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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62199
Species: Mus musculus
RGD Object: Gene
Symbol: Nr1h2
Name: nuclear receptor subfamily 1, group H, member 2
Acc ID: CHEBI:5001
Term: fenofibrate
Definition: A chlorobenzophenone that is (4-chlorophenyl)(phenyl)methanone substituted by a [2-methyl-1-oxo-1-(propan-2-yloxy)propan-2-yl]oxy group at position 1 on the phenyl ring.
Chemical ID: MESH:D011345
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr1h2multiple interactionsEXP 6480464CTDNR1H2 gene mutant form affects the reaction [Fenofibrate results in increased expression of ACACB mRNA]; NR1H2 gene mutant form affects the reaction [Fenofibrate results in increased expression of SCD1 mRNA]; NR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ACACA mRNA]; NR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ACOX1 mRNA]; NR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of CYP4A10 mRNA]; NR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of CYP4A14 mRNA]; NR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ELOVL6 mRNA]; NR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of FASN mRNA]; NR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of FDFT1 mRNA]; NR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of HMGCR mRNA]; NR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of LSS mRNA]; NR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of ME1 mRNA]; NR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of PPARA mRNA]; NR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of SCD2 mRNA]; NR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of SQLE mRNA]; NR1H2 gene mutant form inhibits the reaction [Fenofibrate results in increased expression of SREBF1 mRNA]PMID:23063693
Nr1h2increases expressionISONR1H2 (Homo sapiens)6480464CTDFenofibrate results in increased expression of NR1H2 mRNAPMID:19201410
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