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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1317959
Species: Homo sapiens
RGD Object: Gene
Symbol: AKR1B10
Name: aldo-keto reductase family 1 member B10
Acc ID: CHEBI:5001
Term: fenofibrate
Definition: A chlorobenzophenone that is (4-chlorophenyl)(phenyl)methanone substituted by a [2-methyl-1-oxo-1-(propan-2-yloxy)propan-2-yl]oxy group at position 1 on the phenyl ring.
Chemical ID: MESH:D011345
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
AKR1B10decreases activityEXP 6480464CTDFenofibrate results in decreased activity of AKR1B10 protein, Fenofibrate results in decreased activity of AKR1B10 protein mutant form

PMID:18325492
AKR1B10multiple interactionsEXP 6480464CTDFenofibrate inhibits the reaction [AKR1B10 protein results in increased reduction of Daunorubicin], Fenofibrate inhibits the reaction [AKR1B10 protein results in increased reduction of Glyceraldehyde]

PMID:19028477
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.