GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Edn1 | multiple interactions | EXP | | 6480464 | CTD | Fenofibrate affects the reaction [[AHR protein affects the susceptibility to AGT protein] which affects the expression of EDN1 mRNA] | PMID:31016362 | Edn1 | multiple interactions | ISO | Edn1 (Rattus norvegicus) | 6480464 | CTD | EDN1 protein promotes the reaction [Fenofibrate promotes the reaction [NFATC4 protein binds to PPARA protein]]; Fenofibrate inhibits the reaction [EDN1 protein promotes the reaction [NFATC4 protein binds to GATA4 protein]]; Fenofibrate inhibits the reaction [EDN1 protein promotes the reaction [NFATC4 protein binds to NPPB promoter]]; Fenofibrate inhibits the reaction [EDN1 protein results in increased expression of NPPB mRNA]; PPARA mutant form inhibits the reaction [Fenofibrate inhibits the reaction [EDN1 protein promotes the reaction [NFATC4 protein binds to GATA4 protein]]]; PPARA mutant form inhibits the reaction [Fenofibrate inhibits the reaction [EDN1 protein results in increased expression of NPPB mRNA]] | PMID:22198280 | | ||||||||||||||||||||||
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