GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | ESR1 | affects binding | EXP | | 6480464 | CTD | fenarimol binds to ESR1 protein | PMID:15253041 | ESR1 | decreases expression | EXP | | 6480464 | CTD | fenarimol results in decreased expression of ESR1 mRNA | PMID:15261991 | ESR1 | increases activity | EXP | | 6480464 | CTD | fenarimol results in increased activity of ESR1 protein | PMID:15064155 PMID:20143881 PMID:26812056 | ESR1 | multiple interactions | EXP | | 6480464 | CTD | [Chlorpyrifos co-treated with fenarimol co-treated with Estradiol] results in increased activity of ESR1 protein; afimoxifene inhibits the reaction [[fenarimol co-treated with Estradiol] results in increased activity of ESR1 protein]; afimoxifene inhibits the reaction [fenarimol results in increased activity of ESR1 protein]; fenarimol binds to and results in increased activity of ESR1 protein; fenarimol promotes the reaction [Estradiol results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [[fenarimol co-treated with Estradiol] results in increased activity of ESR1 protein]; Fulvestrant inhibits the reaction [fenarimol results in increased activity of ESR1 protein] | PMID:10789375 PMID:16626760 PMID:26812056 PMID:29162470 PMID:33049310 | |
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