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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2581
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Esr1
Name: estrogen receptor 1
Acc ID: CHEBI:4998
Term: fenarimol
Definition: A racemate comprising equimolar amounts of (R)- and (S)-fenarimol. A sterol demethylation inhibitor, it is used as a fungicide for the treatment of blackspot, mildew and rust in tomatoes, peppers and melons, but is not approved for use within the European Union.
Chemical ID: MESH:C033789
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr1affects bindingISORGD:7365596480464CTDfenarimol binds to ESR1 protein

PMID:15253041
Esr1decreases expressionISORGD:7365596480464CTDfenarimol results in decreased expression of ESR1 mRNA

PMID:15261991
Esr1increases activityISORGD:7365596480464CTDfenarimol results in increased activity of ESR1 protein

PMID:15064155 PMID:20143881 PMID:26812056
Esr1multiple interactionsISORGD:7365596480464CTD[Chlorpyrifos co-treated with fenarimol co-treated with Estradiol] results in increased activity of ESR1 protein afimoxifene inhibits the reaction [[fenarimol co-treated with Estradiol] results in increased activity of ESR1 protein] afimoxifene inhibits the reaction [fenarimol results in increased activity of ESR1 protein] fenarimol binds to and results in increased activity of ESR1 protein fenarimol promotes the reaction [Estradiol results in increased activity of ESR1 protein] Fulvestrant inhibits the reaction [[fenarimol co-treated with Estradiol] results in increased activity of ESR1 protein] Fulvestrant inhibits the reaction [fenarimol results in increased activity of ESR1 protein]

PMID:10789375 PMID:16626760 PMID:26812056 PMID:29162470 PMID:33049310
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