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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1345686
Species: Homo sapiens
RGD Object: Gene
Symbol: CXCL8
Name: C-X-C motif chemokine ligand 8
Acc ID: CHEBI:49976
Term: zinc dichloride
Definition: A compound of zinc and chloride ions in the ratio 1:2. It exists in four crystalline forms, in each of which the Zn(2+) ions are trigonal planar coordinated to four chloride ions.
Chemical ID: MESH:C016837
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CXCL8increases expressionEXP 6480464CTDzinc chloride results in increased expression of CXCL8 mRNAPMID:19428942 PMID:21540303 PMID:27427241
CXCL8increases secretionEXP 6480464CTDzinc chloride results in increased secretion of CXCL8 proteinPMID:19428942 PMID:21842098 PMID:23692033 PMID:27427241
CXCL8multiple interactionsEXP 6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [zinc chloride results in increased secretion of CXCL8 protein]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [zinc chloride results in increased secretion of CXCL8 protein]; Acetylcysteine inhibits the reaction [zinc chloride results in increased secretion of CXCL8 protein]; DUOX1 protein affects the reaction [zinc chloride results in increased secretion of CXCL8 protein]; pyrazolanthrone inhibits the reaction [zinc chloride results in increased secretion of CXCL8 protein]; RELA protein affects the reaction [zinc chloride results in increased secretion of CXCL8 protein]; Thiourea inhibits the reaction [zinc chloride results in increased secretion of CXCL8 protein]PMID:27427241
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