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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10790
Species: Mus musculus
RGD Object: Gene
Symbol: Il1b
Name: interleukin 1 beta
Acc ID: CHEBI:49976
Term: zinc dichloride
Definition: A compound of zinc and chloride ions in the ratio 1:2. It exists in four crystalline forms, in each of which the Zn(2+) ions are trigonal planar coordinated to four chloride ions.
Chemical ID: MESH:C016837
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il1bincreases expressionEXP 6480464CTDzinc chloride results in increased expression of IL1B proteinPMID:18509044
Il1bmultiple interactionsEXP 6480464CTDN-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [zinc chloride results in increased expression of IL1B protein]; NCF1 gene mutant form inhibits the reaction [zinc chloride results in increased expression of IL1B protein]; PARP1 gene mutant form inhibits the reaction [zinc chloride results in increased expression of IL1B protein]; zinc chloride inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein]]PMID:18509044 PMID:19130485
Il1bincreases expressionISOIL1B (Homo sapiens)6480464CTDzinc chloride results in increased expression of IL1B mRNAPMID:27427241
Il1bmultiple interactionsISOIl1b (Rattus norvegicus)6480464CTDzinc chloride inhibits the reaction [Tamoxifen results in increased expression of IL1B protein]PMID:31532279
Il1bmultiple interactionsISOIL1B (Homo sapiens)6480464CTDzinc chloride inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]PMID:9138684
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