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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2916
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ins2
Name: insulin 2
Acc ID: CHEBI:49960
Term: vandetanib
Definition: A quinazoline that is 7-[(1-methylpiperidin-4-yl)methoxy]quinazoline bearing additional methoxy and 4-bromo-2-fluorophenylamino substituents at positions 6 and 4 respectively. Used for the treatment of symptomatic or progressive medullary thyroid cancer in patients with unresectable locally advanced or metastatic disease.
Chemical ID: MESH:C452423
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ins2multiple interactionsISOINS (Homo sapiens)6480464CTDINS protein inhibits the reaction [vandetanib results in decreased phosphorylation of AKT1 protein]; INS protein inhibits the reaction [vandetanib results in decreased phosphorylation of RPS6 protein]PMID:23799852
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