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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620195
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mmp12
Name: matrix metallopeptidase 12
Acc ID: CHEBI:499361
Term: aprepitant
Definition: A morpholine-based antiemetic, which is or the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy. Aprepitant is a selective high-affinity antagonist of human substance P/neurokinin 1 (NK1) receptors.
Chemical ID: MESH:C114556
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mmp12multiple interactionsISORGD:7326946480464CTDaprepitant inhibits the reaction [TAC1 protein results in increased expression of MMP12 mRNA]PMID:18441096
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