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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620103
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bad
Name: BCL2-associated agonist of cell death
Acc ID: CHEBI:499361
Term: aprepitant
Definition: A morpholine-based antiemetic, which is or the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy. Aprepitant is a selective high-affinity antagonist of human substance P/neurokinin 1 (NK1) receptors.
Chemical ID: MESH:C114556
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Badincreases expressionISORGD:7355416480464CTDAprepitant results in increased expression of BAD mRNAPMID:30145367
Badmultiple interactionsISORGD:7355416480464CTDArsenic Trioxide promotes the reaction [Aprepitant results in increased expression of BAD mRNA]PMID:30145367
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