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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737223
Species: Homo sapiens
RGD Object: Gene
Symbol: CXCL12
Name: C-X-C motif chemokine ligand 12
Acc ID: CHEBI:49900
Term: arsenous acid
Definition: An arsenic oxoacid consisting of three hydroxy groups attached to a central arsenic atom.
Chemical ID: MESH:C032793
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CXCL12multiple interactionsEXP 6480464CTDArsenic Trioxide inhibits the reaction [CXCL12 protein results in increased expression of CXCR4 protein]; Arsenic Trioxide inhibits the reaction [CXCL12 protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; RELA protein inhibits the reaction [Arsenic Trioxide inhibits the reaction [CXCL12 protein results in increased expression of CXCR4 protein]]PMID:25047463
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