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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736099
Species: Homo sapiens
RGD Object: Gene
Symbol: ANXA2
Name: annexin A2
Acc ID: CHEBI:49900
Term: arsenous acid
Definition: An arsenic oxoacid consisting of three hydroxy groups attached to a central arsenic atom.
Chemical ID: MESH:C032793
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ANXA2decreases expressionEXP 6480464CTDArsenic Trioxide results in decreased expression of ANXA2 mRNA; Arsenic Trioxide results in decreased expression of ANXA2 proteinPMID:19642359 PMID:19781379 PMID:21223737
ANXA2decreases response to substanceEXP 6480464CTDANXA2 protein results in decreased susceptibility to Arsenic TrioxidePMID:20707922
ANXA2increases expressionEXP 6480464CTDArsenic Trioxide results in increased expression of ANXA2 mRNAPMID:17547211
ANXA2multiple interactionsEXP 6480464CTDArsenic Trioxide affects the localization of and results in decreased expression of ANXA2 protein; Arsenic Trioxide results in decreased expression of and results in increased degradation of ANXA2 mRNAPMID:12165291
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