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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733290
Species: Mus musculus
RGD Object: Gene
Symbol: Akr1c18
Name: aldo-keto reductase family 1, member C18
Acc ID: CHEBI:49900
Term: arsenous acid
Definition: An arsenic oxoacid consisting of three hydroxy groups attached to a central arsenic atom.
Chemical ID: MESH:C032793
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Akr1c18decreases response to substanceISOAKR1C3 (Homo sapiens)6480464CTDAKR1C3 protein results in decreased susceptibility to Arsenic TrioxidePMID:20707922
Akr1c18increases expressionISOAKR1C3 (Homo sapiens)6480464CTDArsenic Trioxide results in increased expression of AKR1C3 mRNAPMID:19128835 PMID:21461292 PMID:26705709
Akr1c18multiple interactionsISOAKR1C3 (Homo sapiens)6480464CTDArsenic Trioxide inhibits the reaction [4-aminophenylarsenoxide binds to AKR1C3 protein]PMID:26598702
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