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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732272
Species: Mus musculus
RGD Object: Gene
Symbol: Mapk8
Name: mitogen-activated protein kinase 8
Acc ID: CHEBI:49900
Term: arsenous acid
Definition: An arsenic oxoacid consisting of three hydroxy groups attached to a central arsenic atom.
Chemical ID: MESH:C032793
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk8increases expressionEXP 6480464CTDArsenic Trioxide results in increased expression of MAPK8 mRNA; Arsenic Trioxide results in increased expression of MAPK8 proteinPMID:34091186
Mapk8increases phosphorylationEXP 6480464CTDArsenic Trioxide results in increased phosphorylation of MAPK8 proteinPMID:15688020
Mapk8increases response to substanceEXP 6480464CTDMAPK8 protein results in increased susceptibility to Arsenic Trioxide; MAPK8 results in increased susceptibility to Arsenic TrioxidePMID:16818652
Mapk8affects response to substanceISOMAPK8 (Homo sapiens)6480464CTDMAPK8 protein affects the susceptibility to Arsenic TrioxidePMID:16818652
Mapk8increases activityISOMAPK8 (Homo sapiens)6480464CTDArsenic Trioxide results in increased activity of MAPK8 proteinPMID:11304686 PMID:12296996 PMID:12931215 PMID:14701702 PMID:16646077
Mapk8increases expressionISOMapk8 (Rattus norvegicus)6480464CTDArsenic Trioxide results in increased expression of MAPK8 mRNAPMID:34037972
Mapk8increases expressionISOMAPK8 (Homo sapiens)6480464CTDArsenic Trioxide results in increased expression of MAPK8 proteinPMID:17374990
Mapk8increases phosphorylationISOMapk8 (Rattus norvegicus)6480464CTDArsenic Trioxide results in increased phosphorylation of MAPK8 proteinPMID:21145380 PMID:27174766 PMID:31734849
Mapk8increases phosphorylationISOMAPK8 (Homo sapiens)6480464CTDArsenic Trioxide results in increased phosphorylation of MAPK8 proteinPMID:18412143 PMID:20534739 PMID:24466103 PMID:31734849 PMID:34303041 PMID:34560123 PMID:36509116
Mapk8increases response to substanceISOMAPK8 (Homo sapiens)6480464CTDMAPK8 results in increased susceptibility to Arsenic TrioxidePMID:20799280
Mapk8multiple interactionsISOMapk8 (Rattus norvegicus)6480464CTDAcetylcysteine inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of MAPK8 protein]; Phloretin inhibits the reaction [Arsenic Trioxide results in increased expression of MAPK8 mRNA]; pyrazolanthrone inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of MAPK8 protein]PMID:21145380 PMID:27174766 PMID:34037972
Mapk8multiple interactionsISOMAPK8 (Homo sapiens)6480464CTD[IL24 protein co-treated with Arsenic Trioxide] results in increased phosphorylation of MAPK8 protein; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of MAPK8 protein]; Arsenic Trioxide promotes the reaction [puerarin results in increased expression of MAPK8 protein]; Arsenic Trioxide results in increased phosphorylation of and results in increased activity of MAPK8 protein; Buthionine Sulfoximine promotes the reaction [Arsenic Trioxide results in increased activity of MAPK8 protein]; Dicumarol inhibits the reaction [Arsenic Trioxide results in increased activity of MAPK8 protein]; indole-5-carboxamide promotes the reaction [Arsenic Trioxide results in increased phosphorylation of and results in increased activity of MAPK8 protein]; KIRA6 inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of MAPK8 protein]; MAP2K4 gene mutant form inhibits the reaction [Arsenic Trioxide results in increased activity of MAPK8 protein]; MAPK8 affects the reaction [[Sulindac co-treated with Arsenic Trioxide] results in increased phosphorylation of BCL2L1 protein]; MAPK8 mutant form inhibits the reaction [Arsenic Trioxide results in increased activity of CASP3 protein]; MAPK8 mutant form inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of BCL2 protein]; MAPK8 mutant form inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of MAPK1 protein]; MAPK8 mutant form inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of MAPK3 protein]; MAPK8 mutant form inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of MAPK9 protein]; MAPK8 protein affects the reaction [Arsenic Trioxide results in decreased phosphorylation of and results in decreased activity of AKT1 protein]; MAPK8 protein affects the reaction [Arsenic Trioxide results in increased activity of CASP3 protein]; MAPK8 protein affects the reaction [Arsenic Trioxide results in increased activity of CASP8 protein]; MAPK8 protein affects the reaction [Arsenic Trioxide results in increased activity of CASP9 protein]; MAPK8 protein affects the reaction [Arsenic Trioxide results in increased expression of PTEN protein]; MAPK9 mutant form inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [Arsenic Trioxide results in increased phosphorylation of and results in increased activity of MAPK8 protein]]; SB 203580 promotes the reaction [Arsenic Trioxide results in increased phosphorylation of and results in increased activity of MAPK8 protein]; SCIO-469 promotes the reaction [Arsenic Trioxide results in increased phosphorylation of and results in increased activity of MAPK8 protein]; selonsertib inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of MAPK8 protein]; Tetradecanoylphorbol Acetate promotes the reaction [Arsenic Trioxide results in increased phosphorylation of and results in increased activity of MAPK8 protein]PMID:14610070 PMID:14701702 PMID:15580305 PMID:15961274 PMID:16818652 PMID:18281123 PMID:18412143 PMID:18822310 PMID:20416161 PMID:20534739 PMID:20799280 PMID:31734849 PMID:34560123
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