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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731792
Species: Mus musculus
RGD Object: Gene
Symbol: Cdkn2b
Name: cyclin dependent kinase inhibitor 2B
Acc ID: CHEBI:49900
Term: arsenous acid
Definition: An arsenic oxoacid consisting of three hydroxy groups attached to a central arsenic atom.
Chemical ID: MESH:C032793
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases methylationISORGD:13487316480464CTDArsenic Trioxide results in decreased methylation of CDKN2B gene

PMID:12679007, PMID:17294728
increases expressionISORGD:13487316480464CTDArsenic Trioxide results in increased expression of CDKN2B mRNA

PMID:11877046, PMID:12667347, PMID:12679007, PMID:12864950
multiple interactionsISORGD:13487316480464CTD[Arsenic Trioxide results in decreased methylation of CDKN2B promoter] which results in increased expression of CDKN2B mRNA, [Valproic Acid co-treated with Arsenic Trioxide] results in increased expression of CDKN2B mRNA

PMID:19099629, PMID:20596618
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.