GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Eif2s1 | increases phosphorylation | EXP | | 6480464 | CTD | Arsenic Trioxide results in increased phosphorylation of EIF2S1 protein | PMID:27638049 | Eif2s1 | multiple interactions | EXP | | 6480464 | CTD | 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of EIF2S1 protein]; 4-phenylbutyric acid inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of EIF2S1 protein] | PMID:27638049 | Eif2s1 | increases expression | ISO | EIF2S1 (Homo sapiens) | 6480464 | CTD | Arsenic Trioxide results in increased expression of EIF2S1 protein modified form | PMID:22922937 | Eif2s1 | increases phosphorylation | ISO | EIF2S1 (Homo sapiens) | 6480464 | CTD | Arsenic Trioxide results in increased phosphorylation of EIF2S1 protein | PMID:25258189 PMID:29486283 PMID:34560123 | Eif2s1 | multiple interactions | ISO | EIF2S1 (Homo sapiens) | 6480464 | CTD | 7-methyl-5-(1-((3-(trifluoromethyl)phenyl)acetyl)-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo(2,3-d)pyrimidin-4-amine inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of EIF2S1 protein]; Arsenic Trioxide promotes the reaction [MSI1 protein binds to EIF2S1 protein modified form]; EIF2AK2 protein affects the reaction [MSI1 protein promotes the reaction [Arsenic Trioxide results in increased phosphorylation of EIF2S1 protein]]; EIF2S1 protein affects the reaction [Arsenic Trioxide promotes the reaction [MSI1 protein results in increased expression of KLF4 protein]]; EIF2S1 protein affects the reaction [Arsenic Trioxide promotes the reaction [MSI1 protein results in increased expression of MYC protein]]; EIF2S1 protein affects the reaction [Arsenic Trioxide promotes the reaction [MSI1 protein results in increased expression of POU5F1 protein]]; EIF2S1 protein affects the reaction [Arsenic Trioxide promotes the reaction [MSI1 protein results in increased expression of SOX2 protein]]; EIF2S1 protein affects the reaction [MSI1 protein promotes the reaction [Arsenic Trioxide results in increased phosphorylation of EIF2AK2 protein]]; MSI1 protein promotes the reaction [Arsenic Trioxide results in increased phosphorylation of EIF2S1 protein]; sulforaphane promotes the reaction [Arsenic Trioxide results in increased expression of EIF2S1 protein modified form] | PMID:22922937 PMID:29486283 PMID:34560123 | | ||||||||||||||||||||||
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