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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 728892
Species: Rattus norvegicus
RGD Object: Gene
Symbol: E2f1
Name: E2F transcription factor 1
Acc ID: CHEBI:49900
Term: arsenous acid
Definition: An arsenic oxoacid consisting of three hydroxy groups attached to a central arsenic atom.
Chemical ID: MESH:C032793
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
E2f1affects methylationISOE2F1 (Homo sapiens)6480464CTDArsenic Trioxide affects the methylation of E2F1 promoterPMID:26046465
E2f1decreases expressionISOE2F1 (Homo sapiens)6480464CTDArsenic Trioxide results in decreased expression of E2F1 proteinPMID:24691991 PMID:25174355 PMID:25335113 PMID:34042274
E2f1increases expressionISOE2F1 (Homo sapiens)6480464CTDArsenic Trioxide results in increased expression of E2F1 mRNAPMID:20016248
E2f1multiple interactionsISOE2F1 (Homo sapiens)6480464CTDArsenic Trioxide inhibits the reaction [TP53 protein binds to E2F1 protein]; Arsenic Trioxide promotes the reaction [RB1 protein binds to E2F1 protein]; TP53 protein promotes the reaction [Arsenic Trioxide results in decreased expression of E2F1 protein]PMID:34042274
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