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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69659
Species: Homo sapiens
RGD Object: Gene
Symbol: ICAM1
Name: intercellular adhesion molecule 1
Acc ID: CHEBI:49900
Term: arsenous acid
Definition: An arsenic oxoacid consisting of three hydroxy groups attached to a central arsenic atom.
Chemical ID: MESH:C032793
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ICAM1decreases expressionEXP 6480464CTDArsenic Trioxide results in decreased expression of ICAM1 mRNAPMID:20471514
ICAM1increases expressionEXP 6480464CTDArsenic Trioxide results in increased expression of ICAM1; Arsenic Trioxide results in increased expression of ICAM1 mRNA; Arsenic Trioxide results in increased expression of ICAM1 proteinPMID:12083632 PMID:18055984 PMID:27750169
ICAM1multiple interactionsEXP 6480464CTD[Arsenic Trioxide co-treated with Bortezomib] results in decreased expression of ICAM1 mRNA; [Tretinoin co-treated with Arsenic Trioxide] results in increased expression of ICAM1 mRNA; AG 1879 promotes the reaction [Arsenic Trioxide promotes the reaction [Tretinoin results in increased expression of ICAM1 protein]]; Arsenic Trioxide promotes the reaction [AG 1879 results in increased expression of ICAM1 protein]; Arsenic Trioxide promotes the reaction [Tretinoin results in increased expression of ICAM1 protein]PMID:15894607 PMID:23864846 PMID:24953245 PMID:25913414
ICAM1increases expressionISOIcam1 (Mus musculus)6480464CTDArsenic Trioxide results in increased expression of ICAM1 mRNAPMID:15073043
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