GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Stat3 | decreases phosphorylation | EXP | | 6480464 | CTD | Arsenic Trioxide results in decreased phosphorylation of STAT3 protein | PMID:28454374 | Stat3 | affects localization | ISO | STAT3 (Homo sapiens) | 6480464 | CTD | Arsenic Trioxide affects the localization of STAT3 protein | PMID:34108876 | Stat3 | affects methylation | ISO | STAT3 (Homo sapiens) | 6480464 | CTD | Arsenic Trioxide affects the methylation of STAT3 promoter | PMID:26046465 | Stat3 | decreases expression | ISO | STAT3 (Homo sapiens) | 6480464 | CTD | Arsenic Trioxide results in decreased expression of STAT3 mRNA; Arsenic Trioxide results in decreased expression of STAT3 protein | PMID:23382965 PMID:34108876 | Stat3 | decreases phosphorylation | ISO | STAT3 (Homo sapiens) | 6480464 | CTD | Arsenic Trioxide results in decreased phosphorylation of STAT3 protein | PMID:25196641 PMID:29409467 PMID:30612216 | Stat3 | increases phosphorylation | ISO | STAT3 (Homo sapiens) | 6480464 | CTD | Arsenic Trioxide results in increased phosphorylation of STAT3 protein | PMID:29396848 | Stat3 | multiple interactions | ISO | Stat3 (Rattus norvegicus) | 6480464 | CTD | 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of and affects the localization of STAT3 protein]; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of STAT3 protein]; Arsenic Trioxide results in increased phosphorylation of and affects the localization of STAT3 protein; pyrazolanthrone inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of and affects the localization of STAT3 protein] | PMID:27174766 | Stat3 | multiple interactions | ISO | STAT3 (Homo sapiens) | 6480464 | CTD | [Arsenic Trioxide results in decreased activity of NOTCH1 protein] which results in decreased phosphorylation of and results in decreased activity of STAT3 protein; [ruxolitinib co-treated with Arsenic Trioxide] results in decreased phosphorylation of STAT3 protein; Arsenic Trioxide inhibits the reaction [IL6 protein results in increased phosphorylation of and results in increased activity of STAT3 protein]; Arsenic Trioxide promotes the reaction [Curcumin results in decreased expression of STAT3 protein]; Arsenic Trioxide results in decreased expression of and results in decreased phosphorylation of STAT3 protein; Arsenic Trioxide results in decreased phosphorylation of and results in decreased activity of STAT3 protein; pervanadate inhibits the reaction [Arsenic Trioxide results in decreased phosphorylation of STAT3 protein]; PTPN6 protein affects the reaction [Arsenic Trioxide results in decreased phosphorylation of STAT3 protein]; STAT3 protein inhibits the reaction [Arsenic Trioxide results in decreased expression of NFKB1 protein]; STAT3 protein inhibits the reaction [Arsenic Trioxide results in decreased expression of RELA protein] | PMID:12492118 PMID:17121903 PMID:23382965 PMID:23542114 PMID:29409467 PMID:30012499 PMID:33634982 PMID:36352148 | | ||||||||||||||||||||||
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