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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62396
Species: Mus musculus
RGD Object: Gene
Symbol: Ddit3
Name: DNA-damage inducible transcript 3
Acc ID: CHEBI:49900
Term: arsenous acid
Definition: An arsenic oxoacid consisting of three hydroxy groups attached to a central arsenic atom.
Chemical ID: MESH:C032793
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects localizationEXP 6480464CTDArsenic Trioxide affects the localization of DDIT3 protein

PMID:27461142
increases expressionEXP 6480464CTDArsenic Trioxide results in increased expression of DDIT3 mRNA, Arsenic Trioxide results in increased expression of DDIT3 protein

PMID:21533816, PMID:23892647, PMID:24157283, PMID:27638049
multiple interactionsEXP 6480464CTD1, 2-Dihydroxybenzene-3, 5-Disulfonic Acid Disodium Salt inhibits the reaction [Arsenic Trioxide results in increased expression of DDIT3 protein], 2-(4-chlorophenoxy)-N-(4-(2-(4-chlorophenoxy)acetamido)cyclohexyl)acetamide inhibits the reaction [Arsenic Trioxide results in increased expression of DDIT3 protein], 4, 4'-Diisothiocyanostilbene-2, 2'-Disulfonic Acid inhibits the reaction [Arsenic Trioxide results in increased expression of DDIT3 protein], 4-phenylbutyric acid inhibits the reaction [Arsenic Trioxide results in increased expression of DDIT3 protein], Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of DDIT3 mRNA], Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of DDIT3 protein], ATF4 protein promotes the reaction [Arsenic Trioxide results in increased expression of DDIT3 protein], DDIT3 mutant form inhibits the reaction [Arsenic Trioxide results in increased activity of CASP3 protein], DDIT3 mutant form inhibits the reaction [Arsenic Trioxide results in increased activity of CASP7 protein], DDIT3 mutant form inhibits the reaction [Arsenic Trioxide results in increased degradation of CASP12 protein], Thapsigargin promotes the reaction [Arsenic Trioxide results in increased expression of DDIT3 protein], Thioctic Acid inhibits the reaction [Arsenic Trioxide results in increased expression of DDIT3 protein]

PMID:21533816, PMID:23892647, PMID:24157283, PMID:27638049
affects expressionISORGD:691656480464CTDArsenic Trioxide affects the expression of DDIT3 mRNA

PMID:12749819
affects response to substanceISORGD:691656480464CTDDDIT3 affects the susceptibility to Arsenic Trioxide

PMID:18172319
increases expressionISORGD:623916480464CTDArsenic Trioxide results in increased expression of DDIT3 protein

PMID:21145380, PMID:23664956
increases expressionISORGD:691656480464CTDArsenic Trioxide results in increased expression of DDIT3 mRNA, Arsenic Trioxide results in increased expression of DDIT3 protein

PMID:11678611, PMID:12883267, PMID:15493360, PMID:18172319, PMID:20458559, PMID:20501519, PMID:22922937, PMID:22959511, PMID:23883479, PMID:24356939, PMID:25258189, PMID:26772155
multiple interactionsISORGD:623916480464CTDAcetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of DDIT3 protein]

PMID:21145380
multiple interactionsISORGD:691656480464CTDAcetylcysteine inhibits the reaction [Arsenic Trioxide promotes the reaction [Resveratrol results in increased expression of DDIT3 protein]], Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of DDIT3 protein], Acetylcysteine inhibits the reaction [Resveratrol promotes the reaction [Arsenic Trioxide results in increased expression of DDIT3 protein]], Arsenic Trioxide promotes the reaction [4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide results in increased expression of DDIT3 mRNA], Arsenic Trioxide promotes the reaction [Resveratrol results in increased expression of DDIT3 protein], Atrazine promotes the reaction [Arsenic Trioxide results in increased expression of DDIT3 mRNA], DDIT3 affects the reaction [Arsenic Trioxide results in increased expression of TNFRSF10B], DDIT3 mutant form inhibits the reaction [Arsenic Trioxide results in increased expression of TNFRSF10B protein], DDIT3 results in increased susceptibility to [Arsenic Trioxide co-treated with TNFSF10], MT2A protein promotes the reaction [Arsenic Trioxide results in increased expression of DDIT3 protein], Resveratrol promotes the reaction [Arsenic Trioxide results in increased expression of DDIT3 protein], sulforafan promotes the reaction [Arsenic Trioxide results in increased expression of DDIT3 protein]

PMID:11678611, PMID:18172319, PMID:19939880, PMID:22922937, PMID:23664956, PMID:23883479, PMID:26772155
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.