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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62252
Species: Mus musculus
RGD Object: Gene
Symbol: Txnrd1
Name: thioredoxin reductase 1
Acc ID: CHEBI:49900
Term: arsenous acid
Definition: An arsenic oxoacid consisting of three hydroxy groups attached to a central arsenic atom.
Chemical ID: MESH:C032793
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Txnrd1affects bindingISOTxnrd1 (Rattus norvegicus)6480464CTDArsenic Trioxide binds to TXNRD1 proteinPMID:17640917
Txnrd1affects expressionISOTXNRD1 (Homo sapiens)6480464CTDArsenic Trioxide affects the expression of TXNRD1 mRNAPMID:25873331
Txnrd1decreases activityISOTxnrd1 (Rattus norvegicus)6480464CTDArsenic Trioxide results in decreased activity of TXNRD1 proteinPMID:17640917
Txnrd1decreases activityISOTXNRD1 (Homo sapiens)6480464CTDArsenic Trioxide results in decreased activity of TXNRD1 proteinPMID:17640917
Txnrd1decreases expressionISOTXNRD1 (Homo sapiens)6480464CTDArsenic Trioxide results in decreased expression of TXNRD1 mRNA; Arsenic Trioxide results in decreased expression of TXNRD1 proteinPMID:31205918
Txnrd1decreases response to substanceISOTXNRD1 (Homo sapiens)6480464CTDTXNRD1 protein results in decreased susceptibility to Arsenic TrioxidePMID:20707922
Txnrd1multiple interactionsISOTxnrd1 (Rattus norvegicus)6480464CTDGlutathione affects the reaction [Arsenic Trioxide results in decreased activity of TXNRD1 protein]; NADP affects the reaction [Arsenic Trioxide results in decreased activity of TXNRD1 protein]PMID:17640917
Txnrd1multiple interactionsISOTXNRD1 (Homo sapiens)6480464CTD[MARVELD1 protein results in decreased susceptibility to Arsenic Trioxide] which results in increased expression of TXNRD1 mRNA; [MARVELD1 protein results in decreased susceptibility to Arsenic Trioxide] which results in increased expression of TXNRD1 protein; [ruxolitinib co-treated with Arsenic Trioxide] results in decreased expression of TXNRD1 mRNA; MARVELD1 protein inhibits the reaction [Arsenic Trioxide results in decreased expression of TXNRD1 mRNA]; MARVELD1 protein inhibits the reaction [Arsenic Trioxide results in decreased expression of TXNRD1 protein]PMID:30012499 PMID:31205918
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