GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Flt3 | decreases phosphorylation | ISO | FLT3 (Homo sapiens) | 6480464 | CTD | Arsenic Trioxide results in decreased phosphorylation of FLT3 protein | PMID:17121903 | Flt3 | increases degradation | ISO | FLT3 (Homo sapiens) | 6480464 | CTD | Arsenic Trioxide results in increased degradation of FLT3 protein mutant form | PMID:32284743 | Flt3 | multiple interactions | ISO | FLT3 (Homo sapiens) | 6480464 | CTD | Arsenic Trioxide inhibits the reaction [bafilomycin A results in increased expression of FLT3 protein modified form]; Arsenic Trioxide promotes the reaction [SQSTM1 protein binds to FLT3 protein mutant form]; ATG5 protein promotes the reaction [Arsenic Trioxide results in increased degradation of FLT3 protein mutant form]; ATG7 protein promotes the reaction [Arsenic Trioxide results in increased degradation of FLT3 protein mutant form]; bafilomycin A inhibits the reaction [Arsenic Trioxide results in increased degradation of FLT3 protein mutant form] | PMID:32284743 | | ||||||||||||||||||||||
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