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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2323
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdkn2a
Name: cyclin-dependent kinase inhibitor 2A
Acc ID: CHEBI:49900
Term: arsenous acid
Definition: An arsenic oxoacid consisting of three hydroxy groups attached to a central arsenic atom.
Chemical ID: MESH:C032793
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdkn2aincreases expressionEXP 6480464CTDArsenic Trioxide results in increased expression of CDKN2A proteinPMID:31734849
Cdkn2adecreases methylationISOCDKN2A (Homo sapiens)6480464CTDArsenic Trioxide results in decreased methylation of CDKN2A gene; Arsenic Trioxide results in decreased methylation of CDKN2A promoterPMID:15191659 PMID:16008847 PMID:16613325
Cdkn2aincreases expressionISOCDKN2A (Homo sapiens)6480464CTDArsenic Trioxide results in increased expression of CDKN2A gene; Arsenic Trioxide results in increased expression of CDKN2A mRNA; Arsenic Trioxide results in increased expression of CDKN2A proteinPMID:12864950 PMID:15191659 PMID:16008847 PMID:16613325 PMID:19769630 PMID:21544632 PMID:23851143 PMID:31734849
Cdkn2amultiple interactionsISOCDKN2A (Homo sapiens)6480464CTD[Arsenic Trioxide co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of CDKN2A mRNA; [Arsenic Trioxide results in decreased methylation of CDKN2A gene] which results in increased expression of CDKN2A mRNA; [Arsenic Trioxide results in decreased methylation of CDKN2A promoter] which results in increased expression of CDKN2A mRNA; Arsenic Trioxide promotes the reaction [Decitabine results in increased expression of CDKN2A mRNA]; Arsenic Trioxide results in increased expression of and affects the localization of CDKN2A protein; Decitabine promotes the reaction [Arsenic Trioxide results in increased expression of CDKN2A mRNA]; GH1 protein promotes the reaction [Arsenic Trioxide results in increased expression of CDKN2A mRNA]; SB 203580 inhibits the reaction [Arsenic Trioxide results in increased expression of CDKN2A protein]PMID:16613325 PMID:18922899 PMID:20416177 PMID:20596618 PMID:23851143 PMID:31734849
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