Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2294
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccne1
Name: cyclin E1
Acc ID: CHEBI:49900
Term: arsenous acid
Definition: An arsenic oxoacid consisting of three hydroxy groups attached to a central arsenic atom.
Chemical ID: MESH:C032793
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccne1affects expressionISOCCNE1 (Homo sapiens)6480464CTDArsenic Trioxide affects the expression of CCNE1 proteinPMID:12962562
Ccne1decreases expressionISOCCNE1 (Homo sapiens)6480464CTDArsenic Trioxide results in decreased expression of CCNE1 mRNA; Arsenic Trioxide results in decreased expression of CCNE1 proteinPMID:12480548 PMID:19236751 PMID:34042274 PMID:34413873
Ccne1decreases methylationISOCCNE1 (Homo sapiens)6480464CTDArsenic Trioxide results in decreased methylation of CCNE1 promoterPMID:29159499
Ccne1increases expressionISOCCNE1 (Homo sapiens)6480464CTDArsenic Trioxide results in increased expression of CCNE1 mRNA; Arsenic Trioxide results in increased expression of CCNE1 proteinPMID:29159499 PMID:29633893
Ccne1multiple interactionsISOCCNE1 (Homo sapiens)6480464CTDArsenic Trioxide promotes the reaction [CCNE1 protein binds to CDKN1A protein]; TP53 protein promotes the reaction [Arsenic Trioxide results in decreased expression of CCNE1 protein]PMID:10850458 PMID:34042274
Go Back to source page   Continue to Ontology report