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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1608349
Species: Mus musculus
RGD Object: Gene
Symbol: Mir21a
Name: microRNA 21a
Acc ID: CHEBI:49900
Term: arsenous acid
Definition: An arsenic oxoacid consisting of three hydroxy groups attached to a central arsenic atom.
Chemical ID: MESH:C032793
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mir21adecreases response to substanceISOMIR21 (Homo sapiens)6480464CTDMIR21 results in decreased susceptibility to Arsenic TrioxidePMID:21187093
Mir21aincreases expressionISOMIR21 (Homo sapiens)6480464CTDArsenic Trioxide results in increased expression of MIR21 mRNAPMID:22072212 PMID:25395240
Mir21aincreases expressionISOMir21 (Rattus norvegicus)6480464CTDArsenic Trioxide results in increased expression of MIR21 mRNAPMID:25395240
Mir21amultiple interactionsISOMIR21 (Homo sapiens)6480464CTDMIR21 mRNA promotes the reaction [Arsenic Trioxide results in decreased expression of KCNH2 protein]; MIR21 mRNA promotes the reaction [Arsenic Trioxide results in decreased expression of SP1 protein]PMID:25395240
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